(Tissue Specific Transplantation Antigen P35B (TSTA3))
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008].
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
Tonetti, Sturla, Bisso, Benatti, De Flora: "Synthesis of GDP-L-fucose by the human FX protein." in: The Journal of biological chemistry, Vol. 271, Issue 44, pp. 27274-9, (1996) (PubMed).
Aliases for TSTA3 蛋白
tissue specific transplantation antigen P35B (TSTA3) 蛋白 tissue specific transplantation antigen P35B (Tsta3) 蛋白 tissue specific transplantation antigen P35B (tsta3) 蛋白 tissue specific transplantation antigen P35B L homeolog (tsta3.L) 蛋白 AI256181 蛋白 FX 蛋白 Fx 蛋白 P35B 蛋白 p35b 蛋白 SDR4E1 蛋白 sdr4e1 蛋白 si:dkey-235d18none 蛋白 TSTA3 蛋白 Tstap35b 蛋白 zgc:101805 蛋白