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抗Human MTTP 抗体:
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抗Rat (Rattus) MTTP 抗体:
Cow (Bovine) Polyclonal MTTP Primary Antibody for WB - ABIN2781495
Lundahl, Skoglund-Andersson, Caslake, Bedford, Stewart, Hamsten, Packard, Karpe: Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. in American journal of physiology. Endocrinology and metabolism 2006
Show all 3 Pubmed References
Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.
The authors conclude that alternate splicing plays a key role in regulating cellular MTP (显示 MT1B 抗体) levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP (显示 MT1B 抗体) activity.
these data reveal clear cellular defects in induced pluripotent stem cells-derived hepatocytes and cardiomyocytes lacking MTTP activity, including a cardiomyocyte-specific regulated stress response to elevated lipids.
two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB (显示 APOB 抗体)) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL (显示 ABL1 抗体)) patients, are reported.
results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD (显示 TSC2 抗体)
Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (显示 APOB 抗体) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB (显示 APOB 抗体) but not of truncated APOB (显示 APOB 抗体). (APOB (显示 APOB 抗体) = apolipoprotein B (显示 APOB 抗体); MTTP = microsomal triglyceride transfer protein)
In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.
High expression of MTTP is associated with high carotid intima-media thickness.
MTP (显示 MT1B 抗体) Gene Variants are associated with Homozygous Familial Hypercholesterolemia.
the N-terminal domain of MTP (显示 MT1B 抗体) is important for its lipid transfer activity
microsomal triglyceride transfer protein, a protein involved in the transfer of lipids onto CD1d (显示 CD1D 抗体), regulates liver natural killer T cell homeostasis in a manner dependent on hepatocyte CD1d (显示 CD1D 抗体).
Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.
data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.
PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN (显示 TSPO 抗体) LIGANDS
Intestine-specific MTP (显示 LAPTM4A 抗体) and global ACAT2 (显示 SOAT2 抗体) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (显示 CSF1R 抗体)
intestine-specific Mttp deletion is beneficial in young septic mice but harmful in aged mice
identified microsomal triglyceride transfer protein, which we show is also under the transcriptional regulation of C/EBPbeta (显示 CEBPB 抗体) and -delta, as a novel player in the presentation of endogenous lipid antigens by adipocytes
effects of reducing either systemic or liver-specific MTP (显示 LAPTM4A 抗体) activity on cholesterol metabolism and reverse cholesterol transport
Data show that combined deletion of microsomal triglyceride transfer protein (Mttp) and liver fatty acid binding protein 1 (L-Fabp (显示 FABP1 抗体)) are protected from lithogenic diet (LD)-induced gallstone formation.
FoxO6 (显示 Foxo6 抗体) is an important signaling molecule upstream of MTP (显示 LAPTM4A 抗体) for regulating hepatic VLDL-TG production
promotes assembly and secretion of human apolipoprotein B (显示 APOB 抗体)
the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB (显示 APOB 抗体) lipoproteins
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (显示 APOB 抗体), ApoE (显示 APOE 抗体), MTP, and LDLR (显示 LDLR 抗体), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100 (显示 APOB 抗体)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E (显示 APOE 抗体) messenger RNA abundance were higher in the liver
measurements of the transfer of phospholipids (PLs (显示 CTSC 抗体)) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity
MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.
There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.
analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit
In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
microsomal triglyceride transfer protein (large polypeptide, 88kDa)
, microsomal triglyceride transfer protein large subunit
, microsomal triglyceride transfer protein B
, microsomal triglyceride transfer protein, large subunit
, microsomal triacylglycerol transfer protein
, microsomal triglyceride transfer protein