(Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP))
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Poduslo, Huang, Huang, Smith: "Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 150B, Issue 1, pp. 50-5, (2009) (PubMed).
Aliases for TRPC4AP 抗体
transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP) 抗体 transient receptor potential cation channel, subfamily C, member 4 associated protein L homeolog (trpc4ap.L) 抗体 transient receptor potential cation channel, subfamily C, member 4 associated protein (trpc4ap) 抗体 transient receptor potential cation channel subfamily C member 4 associated protein (trpc4ap) 抗体 transient receptor potential cation channel, subfamily C, member 4 associated protein (Trpc4ap) 抗体 4833429F06Rik 抗体 C20orf188 抗体 D2Ertd113e 抗体 mFLJ00177 抗体 MGC130977 抗体 TRPC4AP 抗体 Trrp4ap 抗体 TRRP4AP 抗体 truss 抗体 TRUSS 抗体