This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009].
Kan-o, Takeya, Taniguchi, Tanoue, Tominaga, Sumimoto: "Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart." in: PLoS ONE, Vol. 7, Issue 4, pp. e34765, (2012) (PubMed).
Mudry, Perry, Richards, Fowler, Gregorio: "The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 1057-68, (2003) (PubMed).