The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Centner, Yano, Kimura, McElhinny, Pelin, Witt, Bang, Trombitas, Granzier, Gregorio, Sorimachi, Labeit: "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain." in: Journal of molecular biology, Vol. 306, Issue 4, pp. 717-26, (2001) (PubMed).