The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Centner, Yano, Kimura, McElhinny, Pelin, Witt, Bang, Trombitas, Granzier, Gregorio, Sorimachi, Labeit: "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain." in: Journal of molecular biology, Vol. 306, Issue 4, pp. 717-26, (2001) (PubMed).