(Triggering Receptor Expressed On Myeloid Cells-Like 1 (TREML1))
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012].
Vögtle, Sharma, Mori, Nagy, Semeniak, Scandola, Geer, Smith, Lane, Pollack, Lassila, Jouppila, Barr, Ogg, Howard, McMiken, Warwicker, Geh, Rowlinson, Abbott, Eckly, Schulze, Wright, Mazharian et al.: "Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. ..." in: eLife, Vol. 8, (2019) (PubMed).
Nurden, Nurden, Bermejo, Combrié, McVicar, Washington: "Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1." in: Thrombosis and haemostasis, Vol. 100, Issue 1, pp. 45-51, (2008) (PubMed).
Giomarelli, Washington, Chisholm, Quigley, McMahon, Mori, McVicar: "Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1." in: Thrombosis and haemostasis, Vol. 97, Issue 6, pp. 955-63, (2007) (PubMed).