(Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].
Li, Birkenheuer, Marr, Levy, Yoder, Nordone: "Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils." in: Developmental and comparative immunology, Vol. 35, Issue 8, pp. 872-80, (2011) (PubMed).
Ciani, Schulze, Corrigan, Henihan, Giraud, Terry, Walton, Pethig, Ghazal, Crain, Campbell, Bachmann, Mount: "Development of immunosensors for direct detection of three wound infection biomarkers at point of care using electrochemical impedance spectroscopy." in: Biosensors & bioelectronics, Vol. 31, Issue 1, pp. 413-8, (2011) (PubMed).