This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Abdul-Muneer, Alikunju, Schuetz, Szlachetka, Ma, Haorah: "Impairment of Thiamine Transport at the GUT-BBB-AXIS Contributes to Wernicke's Encephalopathy." in: Molecular neurobiology, Vol. 55, Issue 7, pp. 5937-5950, (2018) (PubMed).
Mayr, Freisinger, Schlachter, Rolinski, Zimmermann, Scheffner, Haack, Koch, Ahting, Prokisch, Sperl: "Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway." in: American journal of human genetics, Vol. 89, Issue 6, pp. 806-12, (2011) (PubMed).