This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008].
Matsushima, Takahashi, Nakaya, Maezawa, Miki, Nakamura, Ohgushi, Yasuoka: "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 290, Issue 2, pp. L385-95, (2006) (PubMed).
Böttcher, Matrosovich, Beyerle, Klenk, Garten, Matrosovich: "Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium." in: Journal of virology, Vol. 80, Issue 19, pp. 9896-8, (2006) (PubMed).
Aliases for TMPRSS11D 抗体
transmembrane protease, serine 11D (TMPRSS11D) 抗体 transmembrane protease, serine 11d (Tmprss11d) 抗体 transmembrane protease serine 11D (LOC100720850) 抗体 AsP 抗体 Asp 抗体 AST 抗体 BC020151 抗体 HAT 抗体 Tmprss11d 抗体