Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).
Bakulski, Dolinoy, Sartor, Paulson, Konen, Lieberman, Albin, Hu, Rozek: "Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex." in: Journal of Alzheimer's disease : JAD, Vol. 29, Issue 3, pp. 571-88, (2012) (PubMed).