This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010].
Latest Publications for our TMED7-TICAM2 Readthrough 抗体
Doyle, Husebye, Connolly, Espevik, ONeill, McGettrick: "The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation." in: Nature communications, Vol. 3, pp. 707, (2012) (PubMed).