TLR8 抗体
(Toll-Like Receptor 8 (TLR8))
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008].
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Latest Publications for our TLR8 抗体
: "Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy." in: Clinics and research in hepatology and gastroenterology, (2017) (PubMed).: "The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 64, Issue 8, pp. 470-82, (2017) (PubMed).
: "FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+T Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 198, Issue 12, pp. 4596-4606, (2017) (PubMed).
: "Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination." in: Oncotarget, Vol. 7, Issue 27, pp. 41811-41824, (2016) (PubMed).
: "Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 125, Issue 2, pp. 85-92, (2016) (PubMed).
: "Direct Toll-Like Receptor 8 signaling increases the functional avidity of human CD8+ T lymphocytes generated for adoptive T cell therapy strategies." in: Immunity, inflammation and disease, Vol. 3, Issue 1, pp. 1-13, (2015) (PubMed).
: "TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 3, pp. 1100-11, (2015) (PubMed).
: "Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils." in: Nature communications, Vol. 6, pp. 6061, (2015) (PubMed).
: "Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome." in: Clinical and experimental immunology, Vol. 182, Issue 3, pp. 332-45, (2015) (PubMed).
: "Functional polymorphisms of TLR8 are associated with hepatitis C virus infection." in: Immunology, Vol. 141, Issue 4, pp. 540-8, (2014) (PubMed).
Aliases for TLR8 抗体
toll like receptor 8 (TLR8) 抗体toll-like receptor 8 (Tlr8) 抗体
toll like receptor 8 (Tlr8) 抗体
toll-like receptor 8 (TLR8) 抗体
CD288 抗体
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