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Titin 蛋白

(Titin (TTN))
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012].

6 results :

TTN 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
产品编号 ABIN7125403
 
TTN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
产品编号 ABIN1324075
 
TTN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
产品编号 ABIN1324073
 
TTN 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % WB, SDS, Imm, PC
产品编号 ABIN7423204
 
TTN 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 97 % WB, SDS, Imm, PC
产品编号 ABIN7394549
 
TTN 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS
产品编号 ABIN5712956
 
  • 类型 Protein
    • Protein
  • 应用范围
    • Western Blotting (WB)
    • ELISA
    • SDS-PAGE (SDS)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Immunogen (Imm)
    • Positive Control (PC)
  • 适用
    • Human
    • Mouse
  • 图像
  • 抗体来源
    • Escherichia coli (E. coli)
    • Wheat germ
  • 抗原表位
    • AA 1-110
    • AA 1-305
    • AA 14257-14543
    • AA 33004-33244
    • AA 33779-34025
    • AA 5398-5604
    • partial
  • 标记
    • His tag
    • GST tag
  • 蛋白类型
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Supplier
    • antibodies-online
    • Signalway

Aliases for Titin 蛋白

titin (TTN) 蛋白
titin (Ttn) 蛋白
titin (titin) 蛋白
titin (TTNLOC100620261) 蛋白
1100001C23Rik 蛋白
2310036G12Rik 蛋白
2310057K23Rik 蛋白
2310074I15Rik 蛋白
AF006999 蛋白
AV006427 蛋白
CMD1G 蛋白
CMH9 蛋白
CMPD4 蛋白
D330041I19Rik 蛋白
D830007G01Rik 蛋白
EOMFC 蛋白
HMERF 蛋白
L56 蛋白
LGMD2J 蛋白
mdm 蛋白
MYLK5 蛋白
shru 蛋白
TMD 蛋白
UNC-22 蛋白
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