The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010].
Mukogawa, Koyama, Tachibana, Takayanagi, Shimizu, Fujii, Ueno, Matsumoto, Takeuchi, Nakajima: "Adenovirus-mediated gene transduction of truncated I kappa B alpha enhances radiosensitivity in human colon cancer cells." in: Cancer science, Vol. 94, Issue 8, pp. 745-50, (2003) (PubMed).