(Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3))
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008].
Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
Tamura, Miyata, Sugahara, Onishi, Shuin, Aso: "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain." in: Biochemical and biophysical research communications, Vol. 309, Issue 1, pp. 189-95, (2003) (PubMed).
Kile, Schulman, Alexander, Nicola, Martin, Hilton: "The SOCS box: a tale of destruction and degradation." in: Trends in biochemical sciences, Vol. 27, Issue 5, pp. 235-41, (2002) (PubMed).
Aliases for TCEB3 抗体
Elongin A (EloA) 抗体 transcription elongation factor B polypeptide 3 (LOC413407) 抗体 elongin A (eloa) 抗体 calcium binding and coiled-coil domain 1b (calcoco1b) 抗体 elongin A (ELOA) 抗体 elongin A S homeolog (eloa.S) 抗体 elongin A (Eloa) 抗体 transcription elongation factor B subunit 3 (TCEB3) 抗体 110kDa 抗体 AA408125 抗体 CG6755 抗体 dEloA 抗体 Dmel\\CG6755 抗体 El 抗体 Elo-A 抗体 EloA 抗体 SIII 抗体 SIII p110 抗体 TCEB3 抗体 tceb3a 抗体 Tceb3a 抗体 TCEB3A 抗体 wu:fw66g10 抗体 zgc:56638 抗体