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TBP 产品

(TATA Box Binding Protein (TBP))
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010].

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Featured TBP Categories

TBP 抗体

High quality antibodies with extensive validation data.

TBP ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TBP 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TBP 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (8)
Cat. No. ABIN7193395
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, ELISA, IHC (p)
Validations
  • (8)
Cat. No. ABIN3029100
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, FACS
Validations
  • (6)
Cat. No. ABIN3029099
Quantity 0.4 mL
Datasheet Datasheet

Recommended TBP ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1160973
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method Quantitative
Validations
Cat. No. ABIN1059009
Quantity 96 tests
Datasheet Datasheet
Reactivity Monkey
Analytical Method Quantitative
Validations
Cat. No. ABIN1059008
Quantity 96 tests
Datasheet Datasheet

Recommended TBP 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322267
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133614
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7420309
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TBP Products

Basic, Tadele, Elmabsout, Yao, Rahman, Sirsjö, Abdel-Halim: "Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 303, Issue 6, pp. L519-27, (2012) (PubMed).

Denissov, van Driel, Voit, Hekkelman, Hulsen, Hernandez, Grummt, Wehrens, Stunnenberg: "Identification of novel functional TBP-binding sites and general factor repertoires." in: The EMBO journal, Vol. 26, Issue 4, pp. 944-54, (2007) (PubMed).

Helmlinger, Hardy, Abou-Sleymane, Eberlin, Bowman, Gansmüller, Picaud, Zoghbi, Trottier, Tora, Devys: "Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction." in: PLoS biology, Vol. 4, Issue 3, pp. e67, (2006) (PubMed).

Raha, Cheng, Green: "HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs." in: PLoS biology, Vol. 3, Issue 2, pp. e44, (2005) (PubMed).

Reid, van Roon-Mom, Wood, Rees, Owen, Faull, Dragunow, Snell: "TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease." in: Brain research. Molecular brain research, Vol. 125, Issue 1-2, pp. 120-8, (2004) (PubMed).

Martianov, Brancorsini, Gansmuller, Parvinen, Davidson, Sassone-Corsi: "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids." in: Development (Cambridge, England), Vol. 129, Issue 4, pp. 945-55, (2002) (PubMed).

Brou, Chaudhary, Davidson, Lutz, Wu, Egly, Tora, Chambon: "Distinct TFIID complexes mediate the effect of different transcriptional activators." in: The EMBO journal, Vol. 12, Issue 2, pp. 489-99, (1993) (PubMed).

Hoffman, Sinn, Yamamoto, Wang, Roy, Horikoshi, Roeder: "Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)." in: Nature, Vol. 346, Issue 6282, pp. 387-90, (1990) (PubMed).

Peterson, Tanese, Pugh, Tjian: "Functional domains and upstream activation properties of cloned human TATA binding protein." in: Science (New York, N.Y.), Vol. 248, Issue 4963, pp. 1625-30, (1990) (PubMed).

Kao, Lieberman, Schmidt, Zhou, Pei, Berk: "Cloning of a transcriptionally active human TATA binding factor." in: Science (New York, N.Y.), Vol. 248, Issue 4963, pp. 1646-50, (1990) (PubMed).

Synonyms and alternative names related to TBP

TATA-box binding protein (TBP), TATA box binding protein (Tbp), TATA box binding protein (tbp), TATA box binding protein (TBP), TATA-box binding protein (tbp), TATA binding protein (Tbp), TATA-box binding protein L homeolog (tbp.L), TATA-box binding protein (Tbp), TATA-box-binding protein (Tbp), TATA-box binding protein S homeolog (tbp.S), CG9874, Dmel\\CG9874, dTBP, dTbp, dtbp, dTFIID, fd20h06, GTF2D, Gtf2d, gtf2d, GTF2D1, gtf2d1, HDL4, RBP, SCA17, sca17, si:zc101n13.2, TBP, tbp, tbp-a, tbp-b, TBP1, TBP38, TFIID, TfIID, tfiid, TFIIDtau, tfiidtau, wu:fd20h06, xtbp, zgc:66213

Protein level used designations for TBP

  • TATA sequence-binding protein
  • TATA-box binding protein N-terminal domain
  • TATA-box factor
  • TATA-box-binding protein
  • transcription initiation factor TFIID TBP subunit
  • TATA-binding factor
  • TATA-binding protein
  • TFIID core protein
  • zTBP
  • zfTBF
  • TA-TA binding protein 1
  • TATA binding protein
  • TATA box binding protein
  • 42kDa polypeptide
  • CG9874-PA
  • TATA box-binding protein
  • TATA-box binding protein
  • Tbp-PA
  • transcription factor
  • Transcription initiation factor TFIID TBP subunit
  • TATA-box binding protein S homeolog
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