Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex\; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008].
Hage-Sleiman, Herveau, Matera, Laurier, Dumontet: "Silencing of tubulin binding cofactor C modifies microtubule dynamics and cell cycle distribution and enhances sensitivity to gemcitabine in breast cancer cells." in: Molecular cancer therapeutics, Vol. 10, Issue 2, pp. 303-12, (2011) (PubMed).
Garcia-Mayoral, Castaño, Fanarraga, Zabala, Rico, Bruix: "The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction." in: PLoS ONE, Vol. 6, Issue 10, pp. e25912, (2011) (PubMed).
Hage-Sleiman, Herveau, Matera, Laurier, Dumontet: "Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells." in: BMC cancer, Vol. 10, pp. 135, (2010) (PubMed).
Aliases for TBCC 抗体
tubulin folding cofactor C (TBCC) 抗体 tubulin folding cofactor C (Tbcc) 抗体 tubulin-specific chaperone C (Tbcc) 抗体 2810055C19Rik 抗体 CFC 抗体