May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Stöckli, Davey, Hohnen-Behrens, Xu, James, Ramm: "Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association." in: Molecular endocrinology (Baltimore, Md.), Vol. 22, Issue 12, pp. 2703-15, (2008) (PubMed).
Karlsson, Zierath, Kane, Krook, Lienhard, Wallberg-Henriksson: "Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects." in: Diabetes, Vol. 54, Issue 6, pp. 1692-7, (2005) (PubMed).
Aliases for TBC1D4 抗体
TBC1 domain family member 4 (TBC1D4) 抗体 TBC1 domain family, member 4 (Tbc1d4) 抗体 5930406J04Rik 抗体 A930035N22 抗体 AS160 抗体 As160 抗体 AV295684 抗体 RGD1561609 抗体