(Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1 (TAX1BP1))
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
Wang, Chen, Yeo, Karsli-Uzunbas, White, Mizushima, Virgin, Guan: "Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide." in: The Journal of cell biology, Vol. 212, Issue 5, pp. 545-60, (2016) (PubMed).
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
Newman, Scholefield, Kemp, Newman, McIver, Kamal, Wilkinson: "TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling." in: PLoS ONE, Vol. 7, Issue 11, pp. e50672, (2012) (PubMed).
Aliases for TAX1BP1 抗体
Tax1 binding protein 1 (TAX1BP1) 抗体 Tax1 (human T cell leukemia virus type I) binding protein 1 (Tax1bp1) 抗体 Tax1 binding protein 1 (Tax1bp1) 抗体 Tax1 (human T-cell leukemia virus type I) binding protein 1b (tax1bp1b) 抗体 Tax1 binding protein 1 S homeolog (tax1bp1.S) 抗体 Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1) 抗体 Tax1 (human T-cell leukemia virus type I) binding protein 1a (tax1bp1a) 抗体 Tax1 binding protein 1 L homeolog (tax1bp1.L) 抗体 1200003J11Rik 抗体 1700069J21Rik 抗体 AA930106 抗体 CALCOCO3 抗体 D6Ertd404e 抗体 D6Ertd772e 抗体 MDP62 抗体 MGC132101 抗体 si:ch211-204j16.2 抗体 T6BP 抗体 T6bp 抗体 tax1bp1 抗体 TAX1BP1 抗体 TXBP151 抗体 wu:fc20c12 抗体 wu:fc56e11 抗体 zgc:73219 抗体 zgc:77129 抗体