This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008].
Di Menna, Busceti, Ginerete, DErrico, Orlando, Alborghetti, Bruno, Battaglia, Fornai, Leoni, Rampioni, Visca, Monn, Nicoletti: "The bacterial quorum sensing molecule, 2-heptyl-3-hydroxy-4-quinolone (PQS), inhibits signal transduction mechanisms in brain tissue and is behaviorally active in mice." in: Pharmacological research, Vol. 170, pp. 105691, (2021) (PubMed).