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Human Polyclonal STX17 Primary Antibody for IHC, IHC (p) - ABIN4356685
Jiang, Nishimura, Sakamaki, Itakura, Hatta, Natsume, Mizushima: The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. in Molecular biology of the cell 2014
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Human Polyclonal STX17 Primary Antibody for WB - ABIN657522
Petukhova, Duvic, Hordinsky, Norris, Price, Shimomura, Kim, Singh, Lee, Chen, Meyer, Paus, Jahoda, Amos, Gregersen, Christiano: Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. in Nature 2010
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Homotypic fusion and vacuole protein sorting complex colocalizes and interacts with Syntaxin 17, suggesting their association is critical during tethering and fusion of autophagosomes with lysosomes.
Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29 (显示 SNAP29 抗体)) and VAMP7 (显示 VAMP7 抗体) in Drosophila melanogaster
A 4.6 kb duplication in Syntaxin 17, associated with the Grey phenotype in horses, does not only predispose to melanoma development, but that a copy number expansion of the duplication may be a driving force for melanoma development.
In transgenic zebrafish, a construct with 2 copies of a 4.6-kb intronic duplication is a strong enhancer in neural crest cells but a single copy is a weak enhancer. It contains 2 MITF (显示 MITF 抗体) binding sites.
Both STX17 and the neighboring NR4A3 (显示 NR4A3 抗体) gene are overexpressed in melanomas from Gray horses.
Data suggest that accumulation of autophagosomes confers cytotoxicity in a number of cell types including neurons mimicking neurodegeneration; RNA interference of combinations of MTOR (显示 FRAP1 抗体), VPS33A (显示 VPS33A 抗体), and STX17 lead to accumulation of autophagosomes and cytotoxicity. (MTOR (显示 FRAP1 抗体) = mechanistic target of rapamycin (显示 FRAP1 抗体) kinase; VPS33A (显示 VPS33A 抗体) = vacuolar protein sorting 33A (显示 VPS33A 抗体); STX17 = syntaxin 17)
Pacer recruits PI3KC3 and HOPS (显示 ALPL 抗体) complexes to the autophagosome for their site-specific activation by anchoring to the autophagosomal SNARE (显示 NAPA 抗体) Stx17.
This study demonstrates that the amount of syntaxin 17 decreased in Hepatitis C Virus replicating cells. In addition, syntaxin 17 is identified to be a novel factor controlling the release of HCV, and the relevance of autophagosome-lysosome fusion as a regulator of the amount of released viral particles is revealed.
the homotypic fusion and protein sorting-tethering complex promotes autophagosome-lysosome fusion through interaction with STX17
Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE (显示 NAPA 抗体) required for fusion with the endosome/lysosome.
The syntaxin 17 is essential for maintaining the architecture of ERGIC and Golgi.
Common variants in the STX17 gene region do not play a key role in the pathogenesis of human melanoma.
Syntaxin-17 can be traced to the last eukaryotic common ancestor, hinting that the removal of damaged mitochondrial content may represent one of the earliest vesicle transport routes in the cell.
Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE (显示 VTI1B 抗体) required for fusion with the endosome/lysosome.
Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division (By similarity).
, syntaxin 17