Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq, Jul 2008].
Kang, Tian, Pan, Zald, Li, Deng, Sheng: "Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation." in: Cell, Vol. 132, Issue 1, pp. 137-48, (2008) (PubMed).
Sørensen: "SNARE complexes prepare for membrane fusion." in: Trends in neurosciences, Vol. 28, Issue 9, pp. 453-5, (2005) (PubMed).
Das, Gerwin, Sheng: "Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41221-6, (2003) (PubMed).
Lao, Scheuss, Gerwin, Su, Mochida, Rettig, Sheng: "Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly." in: Neuron, Vol. 25, Issue 1, pp. 191-201, (2000) (PubMed).