SUV39H2 抗体
(Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
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Latest Publications for our SUV39H2 抗体
: "IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP." in: eLife, Vol. 8, (2019) (PubMed).: "Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions." in: Nucleic acids research, Vol. 43, Issue 3, pp. 1869-82, (2015) (PubMed).
: "Histone-modifying genes as biomarkers in hepatocellular carcinoma." in: International journal of clinical and experimental pathology, Vol. 7, Issue 5, pp. 2496-507, (2015) (PubMed).
: "High expressions of histone methylation- and phosphorylation-related proteins are associated with prognosis of oral squamous cell carcinoma in male population of Taiwan." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 513, (2013) (PubMed).
: "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia." in: Molecular and cellular biology, Vol. 31, Issue 10, pp. 1949-58, (2011) (PubMed).
: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability." in: Cell, Vol. 107, Issue 3, pp. 323-37, (2001) (PubMed).
: "Regulation of chromatin structure by site-specific histone H3 methyltransferases." in: Nature, Vol. 406, Issue 6796, pp. 593-9, (2000) (PubMed).
: "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression." in: Molecular and cellular biology, Vol. 20, Issue 24, pp. 9423-33, (2000) (PubMed).
Aliases for SUV39H2 抗体
suppressor of variegation 3-9 homolog 2 (SUV39H2) 抗体suppressor of variegation 3-9 homolog 2 (Drosophila) (Suv39h2) 抗体
suppressor of variegation 3-9 homolog 2 (Suv39h2) 抗体
suppressor of variegation 3-9 homolog 2 (suv39h2) 抗体
suppressor of variegation 3-9 homolog 2 L homeolog (suv39h2.L) 抗体
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AA536750 抗体
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SUV39H2 抗体
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