The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Arasaki, Roy: "Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b." in: Traffic (Copenhagen, Denmark), Vol. 11, Issue 5, pp. 587-600, (2010) (PubMed).
Antonin, Wagner, Riedel, Brose, Jahn: "Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion." in: Molecular and cellular biology, Vol. 22, Issue 5, pp. 1545-54, (2002) (PubMed).
Riedel, Antonin, Fernandez-Chacon, Alvarez de Toledo, Jo, Geppert, Valentijn, Valentijn, Jamieson, Südhof, Jahn: "Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6487-97, (2002) (PubMed).
Li, Low, Miura, Weimbs: "SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes." in: American journal of physiology. Renal physiology, Vol. 283, Issue 5, pp. F1111-22, (2002) (PubMed).