This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008].
Zhang, Jiang, Mao, Demeler, Tao, Pati: "Characterization of the interaction between the cohesin subunits Rad21 and SA1/2." in: PLoS ONE, Vol. 8, Issue 7, pp. e69458, (2013) (PubMed).
Zhang, Kuznetsov, Sharan, Li, Rao, Pati: "A handcuff model for the cohesin complex." in: The Journal of cell biology, Vol. 183, Issue 6, pp. 1019-31, (2008) (PubMed).