The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X\\\\;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Smith, Cronk, Lang, McNeel: "Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer." in: Cancer research, Vol. 71, Issue 21, pp. 6785-95, (2011) (PubMed).
Aliases for SSX2 蛋白
SSX family member 2 (SSX2) 蛋白 protein SSX2 (LOC741661) 蛋白 synovial sarcoma, X breakpoint 2 (Ssx2) 蛋白 CT5.2 蛋白 CT5.2A 蛋白 HD21 蛋白 HOM-MEL-40 蛋白 SSX 蛋白 SSX2 蛋白 SSX3 蛋白