SPPL2B 抗体
(Signal Peptide Peptidase-Like 2B (SPPL2B))
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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12 results
SPPL2B
适用: 人
WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our SPPL2B 抗体
: "BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease." in: Neurobiology of aging, Vol. 35, Issue 7, pp. 1596-604, (2014) (PubMed).: "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins." in: The Journal of biological chemistry, Vol. 279, Issue 49, pp. 50790-8, (2004) (PubMed).
: "Novel class of polytopic proteins with domains associated with putative protease activity." in: Biochemistry. Biokhimii?a, Vol. 67, Issue 7, pp. 826-35, (2002) (PubMed).
: "Identification of signal peptide peptidase, a presenilin-type aspartic protease." in: Science (New York, N.Y.), Vol. 296, Issue 5576, pp. 2215-8, (2002) (PubMed).
: "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 2, pp. 143-50, (2000) (PubMed).
Aliases for SPPL2B 抗体
signal peptide peptidase-like 2 (sppl2) 抗体signal peptide peptidase like 2B (sppl2b) 抗体
signal peptide peptidase like 2B S homeolog (sppl2b.S) 抗体
signal peptide peptidase like 2B (SPPL2B) 抗体
signal peptide peptidase like 2B (Sppl2b) 抗体
signal peptide peptidase-like 2B (Sppl2b) 抗体
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