The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008].
de la Fuente, Manzano-Roman, Blouin, Naranjo, Kocan: "Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells." in: BMC infectious diseases, Vol. 7, pp. 110, (2007) (PubMed).
Tosh, Campbell, Fielding, Sillah, Bah, Gustafson, Manneh, Lisse, Sirugo, Bennett, Aaby, McAdam, Bah-Sow, Lienhardt, Kramnik, Hill: "Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 27, pp. 10364-8, (2006) (PubMed).
Bloch, Nakajima, Gulick, Chiche, Orth, de La Monte, Bloch: "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator." in: Molecular and cellular biology, Vol. 20, Issue 16, pp. 6138-46, (2000) (PubMed).
Aliases for SP110 抗体
SP110 nuclear body protein (SP110) 抗体 Sp110 nuclear body protein (Sp110) 抗体 SP110 nuclear body protein (Sp110) 抗体 52kDa 抗体 5031415C07Rik 抗体 5830484A20Rik 抗体 ENSMUSG00000075603 抗体 IFI41 抗体 IFI75 抗体 Ifi75 抗体 IPR1 抗体 Ipr1 抗体 SP110 抗体 VODI 抗体