This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008].
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Costa, Mazan, Gandillet, Pearson, Lacaud, Kouskoff: "SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development." in: Development (Cambridge, England), Vol. 139, Issue 9, pp. 1587-98, (2012) (PubMed).
Saegusa, Hashimura, Kuwata: "Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 92, Issue 4, pp. 511-21, (2012) (PubMed).
Gandillet, Serrano, Pearson, Lie-A-Ling, Lacaud, Kouskoff: "Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification." in: Blood, Vol. 114, Issue 23, pp. 4813-22, (2009) (PubMed).
Zhang, Huang, Dong, Li, Feng, Pan, Han, Wang, Ren, Su, Huang, Lu: "SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells." in: Cancer letters, Vol. 277, Issue 1, pp. 29-37, (2009) (PubMed).