This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008].
Valensi, Goldman, Marchant, Van Den Berghe, Jonet, Daruich, Robert, Krejci, Klein, Mascarelli, Versaux-Botteri, Moulin, Putterman, Guimiot, Molina, Terris, Brémond-Gignac, Behar-Cohen, Abitbol: "Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes." in: Graefe's archive for clinical and experimental ophthalmology, (2019) (PubMed).