This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [provided by RefSeq, Jul 2008].
Ma, Robinson, Chircop: "Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation." in: PLoS ONE, Vol. 8, Issue 7, pp. e68387, (2013) (PubMed).
Ma, Chircop: "SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis." in: Journal of cell science, Vol. 125, Issue Pt 18, pp. 4372-82, (2012) (PubMed).
Soulet, Yarar, Leonard, Schmid: "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis." in: Molecular biology of the cell, Vol. 16, Issue 4, pp. 2058-67, (2005) (PubMed).