This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012].
Yu, Bi, Zheng, Ji, Chevalier, Agarwal, Ramachandran, Li, Lagrange, Walker, Chen: "The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 29, pp. 10073-8, (2008) (PubMed).
Aliases for SNIP1 抗体
Smad nuclear interacting protein 1 (snip1) 抗体 Smad nuclear interacting protein 1 S homeolog (snip1.S) 抗体 Smad nuclear interacting protein 1 (SNIP1) 抗体 smad nuclear interacting protein 1 (CC1G_02914) 抗体 smad nuclear interacting protein 1 (PTRG_06240) 抗体 MYST/Esa1 associated factor 6 (MEAF6) 抗体 Smad nuclear interacting protein 1 (Snip1) 抗体 2410133M08Rik 抗体 MGC75890 抗体 PMRED 抗体 SNIP1 抗体 snip1a 抗体