SMC1A 抗体
(Structural Maintenance of Chromosomes 1A (SMC1A))
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008].
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Latest Publications for our SMC1A 抗体
: "ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib." in: Translational oncology, Vol. 10, Issue 2, pp. 190-196, (2017) (PubMed).: "Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation." in: The EMBO journal, Vol. 34, Issue 10, pp. 1399-416, (2015) (PubMed).
: "Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators." in: Experimental hematology, Vol. 43, Issue 6, pp. 448-61.e2, (2015) (PubMed).
: "The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation." in: eLife, Vol. 3, pp. e03297, (2014) (PubMed).
: "SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs." in: Nature communications, Vol. 4, pp. 1824, (2013) (PubMed).
: "Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 49, pp. 19920-5, (2013) (PubMed).
: "Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53." in: EMBO molecular medicine, Vol. 4, Issue 6, pp. 515-27, (2012) (PubMed).
: "Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines." in: Experimental hematology, Vol. 40, Issue 10, pp. 800-10, (2012) (PubMed).
: "Loss of ATM kinase activity leads to embryonic lethality in mice." in: The Journal of cell biology, Vol. 198, Issue 3, pp. 295-304, (2012) (PubMed).
: "Synergistic cytotoxicity of the DNA alkylating agent busulfan, nucleoside analogs and suberoylanilide hydroxamic acid in lymphoma cell lines." in: Leukemia & lymphoma, Vol. 53, Issue 5, pp. 973-81, (2012) (PubMed).
Aliases for SMC1A 抗体
structural maintenance of chromosomes 1A (SMC1A) 抗体structural maintenance of chromosomes 1A (smc1a) 抗体
structural maintenance of chromosomes 1A (Smc1a) 抗体
structural maintenance of chromosomes 1A b (smc1ab) 抗体
structural maintenance of chromosomes 1A L homeolog (smc1a.L) 抗体
5830426I24Rik 抗体
CDLS2 抗体
DXS423E 抗体
mKIAA0178 抗体
NV15570 抗体
SB1.8 抗体
Sb1.8 抗体
SMC-1A 抗体
SMC1 抗体
Smc1 抗体
smc1 抗体
smc1a 抗体
smc1aa 抗体
SMC1alpha 抗体
Smc1alpha 抗体
SMC1L1 抗体
Smc1l1 抗体
smc1l1 抗体
SMCB 抗体
Smcb 抗体
xSMC1 抗体
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