The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
custom-made
SMAD7
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
SMAD7
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
SMAD family member 7 (SMAD7) 蛋白 SMAD family member 7 (Smad7) 蛋白 SMAD family member 7 L homeolog (smad7.L) 蛋白 SMAD family member 7 (smad7) 蛋白 CRCS3 蛋白 MADH7 蛋白 Madh7 蛋白 madh7 蛋白 MADH8 蛋白 Smad7a 蛋白 Smad10 蛋白 wu:fj60c10 蛋白 xsmad7 蛋白