The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Piotrowski, Kiszałkiewicz, Górski, Antczak, Górski, Pastuszak-Lewandoska, Migdalska-Sęk, Domańska-Senderowska, Nawrot, Czarnecka, Kurmanowska, Brzeziańska-Lasota: "Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients." in: BMC immunology, Vol. 16, pp. 58, (2015) (PubMed).
Aliases for SMAD7 ELISA试剂盒
SMAD family member 7 (SMAD7) ELISA试剂盒 SMAD family member 7 (Smad7) ELISA试剂盒 SMAD family member 7 L homeolog (smad7.L) ELISA试剂盒 SMAD family member 7 (smad7) ELISA试剂盒 CRCS3 ELISA试剂盒 MADH7 ELISA试剂盒 Madh7 ELISA试剂盒 madh7 ELISA试剂盒 MADH8 ELISA试剂盒 Smad7a ELISA试剂盒 Smad10 ELISA试剂盒 wu:fj60c10 ELISA试剂盒 xsmad7 ELISA试剂盒