SLUG 抗体
(Snail Family Zinc Finger 2 (SNAI2))
Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.
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78 results
SNAI2
适用: 兔
WB, ELISA, IF, IP
宿主: 兔
Monoclonal
PT0536R
unconjugated
Recombinant Antibody
Latest Publications for our SLUG 抗体
: "SLUG/HIF1-α/miR-221 regulatory circuit in endometrial cancer." in: Gene, Vol. 711, pp. 143938, (2019) (PubMed).
: "CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo." in: Urologic oncology, Vol. 36, Issue 6, pp. 312.e1-312.e8, (2018) (PubMed).
: "Immunoexpression of transcription factors in urothelial bladder carcinomas." in: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, Vol. 58, Issue 3, pp. 863-869, (2018) (PubMed).
: "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling." in: Cell death & disease, Vol. 9, Issue 8, pp. 802, (2018) (PubMed).
: "The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer." in: Oncogenesis, Vol. 6, Issue 5, pp. e330, (2017) (PubMed).
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation." in: Oncogene, Vol. 36, Issue 42, pp. 5885-5896, (2017) (PubMed).
: "RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin." in: Oncogene, (2016) (PubMed).
: "Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells." in: International journal of oncology, Vol. 48, Issue 3, pp. 1085-94, (2016) (PubMed).
: "Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-κB activation." in: OncoTargets and therapy, Vol. 9, pp. 1011-21, (2016) (PubMed).
: "CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo." in: Urologic oncology, Vol. 36, Issue 6, pp. 312.e1-312.e8, (2018) (PubMed).
: "Immunoexpression of transcription factors in urothelial bladder carcinomas." in: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, Vol. 58, Issue 3, pp. 863-869, (2018) (PubMed).
: "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling." in: Cell death & disease, Vol. 9, Issue 8, pp. 802, (2018) (PubMed).
: "The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer." in: Oncogenesis, Vol. 6, Issue 5, pp. e330, (2017) (PubMed).
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation." in: Oncogene, Vol. 36, Issue 42, pp. 5885-5896, (2017) (PubMed).
: "RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin." in: Oncogene, (2016) (PubMed).
: "Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells." in: International journal of oncology, Vol. 48, Issue 3, pp. 1085-94, (2016) (PubMed).
: "Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-κB activation." in: OncoTargets and therapy, Vol. 9, pp. 1011-21, (2016) (PubMed).
Aliases for SLUG 抗体
snail family transcriptional repressor 2 (Snai2) 抗体snail family zinc finger 2 (Snai2) 抗体
Slug 抗体
Slugh 抗体
Snail2 抗体
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