SLC8A1 产品
(Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))
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In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004].
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Featured SLC8A1 Categories
SLC8A1 抗体
High quality antibodies with extensive validation data.
SLC8A1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SLC8A1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SLC8A1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN6148050
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652886
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7043754
Quantity
25 μL
Datasheet
Datasheet
Recommended SLC8A1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970358
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN579538
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN809058
Quantity
96 tests
Datasheet
Datasheet
Recommended SLC8A1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3093996
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3134653
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3113412
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SLC8A1 Products
: "Effectiveness of gene delivery systems for pluripotent and differentiated cells." in: Molecular therapy. Methods & clinical development, Vol. 2, pp. 14067, (2015) (PubMed).: "Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure." in: Nature communications, Vol. 6, pp. 7229, (2015) (PubMed).
: "Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 5, pp. 988-97, (2012) (PubMed).
: "Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit." in: The Journal of biological chemistry, Vol. 283, Issue 4, pp. 2192-202, (2008) (PubMed).
: "Na+/Ca2+ exchange inhibition protects the rat heart from ischemia-reperfusion injury by blocking energy-wasting processes." in: American journal of physiology. Heart and circulatory physiology, Vol. 288, Issue 4, pp. H1699-707, (2005) (PubMed).
: "Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity." in: Cell, Vol. 120, Issue 2, pp. 275-85, (2005) (PubMed).
: "Neurodegeneration: cellular defences destroyed." in: Nature, Vol. 433, Issue 7027, pp. 696-8, (2005) (PubMed).
: "Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes." in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 139, Issue 2, pp. 133-41, (2004) (PubMed).
: "Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling." in: Circulation research, Vol. 92, Issue 5, pp. e52-9, (2003) (PubMed).
: "Regulation of phosphatidylinositol-4,5-biphosphate bound to the bovine cardiac Na+/Ca2+ exchanger." in: Annals of the New York Academy of Sciences, Vol. 976, pp. 288-99, (2002) (PubMed).
Synonyms and alternative names related to SLC8A1
solute carrier family 8 member A1 (SLC8A1), solute carrier family 8 (sodium/calcium exchanger), member 1 (Slc8a1), solute carrier family 8 member A1 (Slc8a1), solute carrier family 8 (sodium/calcium exchanger), member 1b (slc8a1b), sodium/calcium exchanger 1 (Tsp_07038), AI852629, AV344025, D930008O12Rik, Ncx, NCX1, Ncx1, ncx1n, SLC8A1Protein level used designations for SLC8A1
- Na(+)/Ca(2+)-exchange protein 1
- Na+/Ca++ exchanger
- Na+/Ca2+ exchanger
- sodium/calcium exchanger 1
- Na/Ca exchanger
- sodium/calcium exchanger isoform NaCa7
- Na-Ca exchanger
- solute carrier family 8, member 1
- sodium-calcium exchanger
- solute carrier family 8 (sodium/calcium exchanger), member 1
- ncx1b
- sodium calcium exchanger 1n
- sodium/calcium exchanger
- sodium/calcium exchanger 1-like
- sodium/calcium exchanger isoform NaCa13
- sodium/calcium exchanger isoform NaCa3
- sodium/calcium exchanger isoform NaCa9
- solute carrier family 8 member 1
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