(Solute Carrier Family 35 (UDP-Glucuronic Acid/UDP-N-Acetylgalactosamine Dual Transporter), Member D1 (SLC35D1))
Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009].
Hiraoka, Furuichi, Nishimura, Shibata, Yanagishita, Rimoin, Superti-Furga, Nikkels, Ogawa, Katsuyama, Toyoda, Kinoshita-Toyoda, Ishida, Isono, Sanai, Cohn, Koseki, Ikegawa: "Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human." in: Nature medicine, Vol. 13, Issue 11, pp. 1363-7, (2007) (PubMed).
Ishida, Kawakita: "Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)." in: Pflügers Archiv : European journal of physiology, Vol. 447, Issue 5, pp. 768-75, (2004) (PubMed).
Muraoka, Kawakita, Ishida: "Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity." in: FEBS letters, Vol. 495, Issue 1-2, pp. 87-93, (2001) (PubMed).
Aliases for SLC35D1 抗体
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (Tc00.1047053510611.20) 抗体 UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (Tc00.1047053506793.40) 抗体 solute carrier family 35 member D1 (SLC35D1) 抗体 solute carrier family 35 member D1 (Slc35d1) 抗体 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (Slc35d1) 抗体 AI834976 抗体 C330011J09 抗体 mKIAA0260 抗体 UGTREL7 抗体