The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008].
Abdulnour-Nakhoul, Nakhoul, Kalliny, Gyftopoulos, Rabon, Doetjes, Brown, Nakhoul: "Ion transport mechanisms linked to bicarbonate secretion in the esophageal submucosal glands." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 301, Issue 1, pp. R83-96, (2011) (PubMed).
Aliases for SLC26A3 抗体
solute carrier family 26 member 3 (SLC26A3) 抗体 solute carrier family 26, member 3 (Slc26a3) 抗体 solute carrier family 26 member 3 (Slc26a3) 抗体 solute carrier family 26 (anion exchanger), member 3 (slc26a3.1) 抗体 9030623B18Rik 抗体 9130013M11Rik 抗体 AV376035 抗体 CLD 抗体 DRA 抗体 Dra 抗体 si:dkey-31f5.2 抗体 SLC26A3 抗体