This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008].
Mallampalli, Glasser, Coon, Chen: "Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 663-73, (2013) (PubMed).
Aliases for SKP1 蛋白
S-phase kinase associated protein 1 (SKP1) 蛋白 S-phase kinase-associated protein 1 (skp1) 蛋白 S-phase kinase-associated protein 1 pseudogene (LOC100340043) 蛋白 S-phase kinase associated protein 1 (skp1) 蛋白 S-phase kinase-associated protein 1A (Skp1a) 蛋白 S-phase kinase-associated protein 1 (Skp1) 蛋白 S-phase kinase-associated protein 1 S homeolog (skp1.S) 蛋白 S-phase kinase-associated protein 1 (SKP1) 蛋白 S phase kinase-associated protein 1 (SKP1) 蛋白 S-phase kinase associated protein 1 (Skp1) 蛋白 15kDa 蛋白 2610043E24Rik 蛋白 2610206H23Rik 蛋白 ARABIDOPSIS SKP1 HOMOLOGUE 1 蛋白 ASK1 蛋白 ATSKP1 蛋白 EMC19 蛋白 emc19 蛋白 ocp-2 蛋白 OCP-II 蛋白 ocp-ii 蛋白 OCP2 蛋白 ocp2 蛋白 p19A 蛋白 p19Skp1 蛋白 SKP1 蛋白 SKP1A 蛋白 Skp1a 蛋白 skp1a 蛋白 S phase kinase-associated protein 1 蛋白 T4O12.17 蛋白 T4O12_17 蛋白 TCEB1L 蛋白 Tceb1l 蛋白 tceb1l 蛋白 UFO INTERACTING PROTEIN 1 蛋白 UIP1 蛋白 zgc:73186 蛋白