SIGIRR 蛋白
(Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
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Aliases for SIGIRR 蛋白
single Ig and TIR domain containing (SIGIRR) 蛋白single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr) 蛋白
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr) 蛋白
single Ig and TIR domain containing (Sigirr) 蛋白
AI256711 蛋白
RGD1306732 蛋白
sc:d148 蛋白
TIR8 蛋白
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