(SHC (Src Homology 2 Domain Containing) Family, Member 4 (SHC4))
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Azzalin, Moretti, Arbustini, Magrassi: "Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation." in: Journal of neuro-oncology, Vol. 120, Issue 2, pp. 245-56, (2014) (PubMed).
Jones, Hardy, Friese, Jorgensen, Smith, Woody, Burden, Pawson: "Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase." in: Molecular and cellular biology, Vol. 27, Issue 13, pp. 4759-73, (2007) (PubMed).
Fagiani, Giardina, Luzi, Cesaroni, Quarto, Capra, Germano, Bono, Capillo, Pelicci, Lanfrancone: "RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas." in: Cancer research, Vol. 67, Issue 7, pp. 3064-73, (2007) (PubMed).