SHC1 抗体
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
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Latest Publications for our SHC1 抗体
: "Protective Effects of Curcumin against Sodium Arsenite-induced Ovarian Oxidative Injury in a Mouse Model." in: Chinese medical journal, Vol. 130, Issue 9, pp. 1026-1032, (2018) (PubMed).
: "Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells." in: British journal of cancer, Vol. 110, Issue 3, pp. 706-14, (2014) (PubMed).
: "Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of..." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 10, pp. 2306-17, (2010) (PubMed).
: "Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response." in: Cancer research, Vol. 70, Issue 20, pp. 7776-87, (2010) (PubMed).
: "Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 30, pp. 13420-5, (2010) (PubMed).
: "Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21537-48, (2010) (PubMed).
: "p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior." in: Oncogene, Vol. 29, Issue 41, pp. 5559-67, (2010) (PubMed).
: "Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. ..." in: Nature methods, Vol. 5, Issue 12, pp. 1011-7, (2008) (PubMed).
: "Combinatorial ShcA docking interactions support diversity in tissue morphogenesis." in: Science (New York, N.Y.), Vol. 317, Issue 5835, pp. 251-6, (2007) (PubMed).
: "Role of Shc in T-cell development and function." in: Immunological reviews, Vol. 191, pp. 183-95, (2003) (PubMed).
: "Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells." in: British journal of cancer, Vol. 110, Issue 3, pp. 706-14, (2014) (PubMed).
: "Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of..." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 10, pp. 2306-17, (2010) (PubMed).
: "Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response." in: Cancer research, Vol. 70, Issue 20, pp. 7776-87, (2010) (PubMed).
: "Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 30, pp. 13420-5, (2010) (PubMed).
: "Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21537-48, (2010) (PubMed).
: "p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior." in: Oncogene, Vol. 29, Issue 41, pp. 5559-67, (2010) (PubMed).
: "Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. ..." in: Nature methods, Vol. 5, Issue 12, pp. 1011-7, (2008) (PubMed).
: "Combinatorial ShcA docking interactions support diversity in tissue morphogenesis." in: Science (New York, N.Y.), Vol. 317, Issue 5835, pp. 251-6, (2007) (PubMed).
: "Role of Shc in T-cell development and function." in: Immunological reviews, Vol. 191, pp. 183-95, (2003) (PubMed).
Aliases for SHC1 抗体
SHC adaptor protein 1 (SHC1) 抗体Shc1p (SHC1) 抗体
squalene--hopene cyclase (shc1) 抗体
SHC adaptor protein 1 (Shc1) 抗体
SHC (Src homology 2 domain containing) transforming protein 1 (shc1) 抗体
SHC (Src homology 2 domain containing) transforming protein 1 L homeolog (shc1.L) 抗体
src homology 2 domain-containing transforming protein C1 (Shc1) 抗体
p66 抗体
P66shc 抗体
p66shc 抗体
SHC 抗体
shc 抗体
Shc 抗体
SHC1 抗体
SHCA 抗体
ShcA 抗体
si:dkey-246i14.4 抗体
wu:fc10h03 抗体
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