(Src Homology 2 Domain Containing Adaptor Protein B (SHB))
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Zhang, Zhu, Wang, Liu, Jiao, Liu, Zhang, Lu, He: "Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth." in: Journal of cell science, Vol. 119, Issue Pt 8, pp. 1666-76, (2006) (PubMed).
Saldeen, Kriz, Agren, Welsh: "SHB and angiogenic factors promote ES cell differentiation to insulin-producing cells." in: Biochemical and biophysical research communications, Vol. 344, Issue 2, pp. 517-24, (2006) (PubMed).
Kriz, Agren, Lindholm, Lenell, Saldeen, Mares, Welsh: "The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34484-91, (2006) (PubMed).
Aliases for SHB 抗体
SH2 domain containing adaptor protein B (SHB) 抗体 SH2 domain containing adaptor protein B (Shb) 抗体 src homology 2 domain-containing transforming protein B (Shb) 抗体 bA3J10.2 抗体 BC028832 抗体 RGD1565350 抗体 RP11-3J10.8 抗体 SHB 抗体