SHANK2 产品
(SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
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This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Latest Publications for our SHANK2 Products
: "A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders." in: Journal of neurodevelopmental disorders, Vol. 10, Issue 1, pp. 15, (2018) (PubMed).: "Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo." in: Journal of cell science, Vol. 128, Issue 4, pp. 768-80, (2015) (PubMed).
: "Identification and functional characterization of rare SHANK2 variants in schizophrenia." in: Molecular psychiatry, (2015) (PubMed).
: "Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice." in: Molecular neurodegeneration, Vol. 9, Issue 1, pp. 61, (2015) (PubMed).
: "Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear." in: Hearing research, Vol. 321, pp. 52-64, (2015) (PubMed).
: "S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 5, pp. 1892-904, (2015) (PubMed).
: "Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities." in: Neuroscience, Vol. 304, pp. 286-301, (2015) (PubMed).
: "Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures." in: American journal of human genetics, Vol. 94, Issue 1, pp. 87-94, (2014) (PubMed).
: "Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation." in: Neuroscience, Vol. 266, pp. 80-90, (2014) (PubMed).
: "Casein kinase 2 phosphorylates GluA1 and regulates its surface expression." in: The European journal of neuroscience, Vol. 39, Issue 7, pp. 1148-58, (2014) (PubMed).
Synonyms and alternative names related to SHANK2
SH3 and multiple ankyrin repeat domains 2 (SHANK2), SH3 and multiple ankyrin repeat domains 2 (Shank2), SH3 and multiple ankyrin repeat domains 2 L homeolog (shank2.L), SH3 and multiple ankyrin repeat domains 2 (shank2), SH3 and multiple ankyrin repeat domains protein 2 (LOC100438523), AUTS17, auts17, CORTBP1, cortbp1, CortBP1, CTTNBP1, cttnbp1, MGC122482, mKIAA1022, ProSAP1, prosap1, SHANK, shank2, SHANK2, SPANK-3, spank-3, Spank-3Protein level used designations for SHANK2
- GKAP/SAPAP interacting protein
- SH3 and multiple ankyrin repeat domains protein 2
- cortactin SH3 domain-binding protein
- cortactin-binding protein 1
- proline-rich synapse associated protein 1
- proline-rich synapse-associated protein 1
- cortBP1
- SH3 and multiple ankyrin repeat domains 2
- SH3/ankyrin domain gene 2
- SH3 and multiple ankyrin repeat domains protein 2-like
- GKAP/SAPAP-interacting protein
- proline rich synapse associated protein 1
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