This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Marois, Vaillancourt, Paré, Gagné, Fernandes, Rollet-Labelle, Naccache: "CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils." in: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 15073-84, (2011) (PubMed).