This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Tavasoli, Al-Momany, Wang, Li, Edwards, Ballermann: "Both CLIC4 and CLIC5A activate ERM proteins in glomerular endothelium." in: American journal of physiology. Renal physiology, Vol. 311, Issue 5, pp. F945-F957, (2016) (PubMed).
Wegner, Al-Momany, Kulak, Kozlowski, Obeidat, Jahroudi, Paes, Berryman, Ballermann: "CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity." in: American journal of physiology. Renal physiology, Vol. 298, Issue 6, pp. F1492-503, (2010) (PubMed).
Li, Yin, Ni, Liu, Zhang, Du: "Chloride intracellular channel 5 modulates adipocyte accumulation in skeletal muscle by inhibiting preadipocyte differentiation." in: Journal of cellular biochemistry, Vol. 110, Issue 4, pp. 1013-21, (2010) (PubMed).