兔 anti-人 IgM Chain C (AA 391-440) Antibody
ELISA, WB, IF, IHC
Polyclonal
IgG
unconjugated
产品编号 ABIN7862461
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for 兔 anti-人 IgM Chain C (AA 391-440) Antibody (ABIN7862461)
抗原
IgM Chain C
克隆类型
多克隆
应用范围
ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
亚型
IgG
-
-
抗原表位
- AA 391-440
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
原理
- Rabbit Anti-IgM Chain C Polyclonal Antibody
-
特异性
- IgM Chain C Polyclonal Antibody detects endogenous levels of IgM Chain C.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Synthesized peptide derived from IgM Chain C at AA range: 391-440
-
-
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC: 100-300,WB 1:500-2000,ELISA 1:10000-20000,IF 1:50-200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- IgM Chain C
-
背景
- Ig mu chain C regionIgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30 % of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
-
分子量
- 50kD
-
UniProt
- P01871
抗原
-
You are here:
