小鼠 anti-人 IgD Antibody
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北京 101111
Quick Overview for 小鼠 anti-人 IgD Antibody (ABIN7670067)
抗原
克隆类型
应用范围
克隆位点
亚型
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适用
- 人
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宿主
- 小鼠
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原理
- Purified Anti-Human IgD Antibody[IA6-2]
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Mouse anti-Human IgD antibody
FACS, IHC (fro) Monoclonal IA6-2 IgG2a unconjugated
Mouse anti-Human IgD antibody (APC)FACS Monoclonal IA6-2 IgG2a APC
Mouse anti-Human IgD antibody (PE)FACS Monoclonal IA6-2 IgG2a PE
Goat anti-Human IgD antibody (PE)FACS, ELISA Polyclonal IgG PE
Mouse anti-Human IgD antibody (Biotin)FACS, ELISA Monoclonal IADB6 IgG2a Biotin
Goat anti-Human IgD (Heavy Chain) antibodyFACS, ELISA, WB Polyclonal IgG unconjugated
Goat anti-Human IgD antibodyFACS, ELISA Polyclonal IgG unconjugated F(ab')2 fragment
Goat anti-Human IgD (Heavy Chain) antibody (TRITC)FACS, ELISA Polyclonal IgG TRITC
Goat anti-Human IgD (Heavy Chain) antibody (FITC)FACS, ELISA Polyclonal IgG FITC
Goat anti-Human IgD (Heavy Chain) antibody (Biotin)FACS, ELISA, WB Polyclonal IgG Biotin
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- ≥ 1 mg/mL
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze / thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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有效期
- 12 months
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- IgD
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物质类
- Antibody
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背景
- IGD,Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD
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UniProt
- P0DOX3
抗原
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